Methods, application insights, and new column updates
Zodiac HPLC columns are designed using ultra-pure silica and controlled bonding technologies to deliver consistent and efficient separations across a wide range of analytical applications. The portfolio includes multiple chemistries to support reversed phase, normal phase, and HILIC methods.


The universal standard for reversed-phase chromatography. This premium octadecylsilane phase delivers high theoretical plates, robust retention, and exceptional resolution for a wide array of hydrophobic and moderately polar compounds.
L1

A high-performance octylsilane phase offering reduced hydrophobicity compared to C18. It provides significantly faster elution times for highly retained non-polar compounds while maintaining excellent peak symmetry.
L7

Engineered with an alternative carbon load and proprietary end-capping. This phase provides orthogonal selectivity to standard C18 columns, making it optimal for resolving closely eluting structural isomers.
L1

A tailored C8 stationary phase developed to offer distinct alternative selectivity. It delivers rapid, highly efficient separations specifically targeted for moderately polar analytes.
L7

A robust phenyl bonded phase that provides distinct alternative selectivity to standard C18 columns, optimized specifically for the separation of aromatic and highly polarizable molecules.
L11

A versatile cyanopropyl bonded phase known for its rapid equilibration. It functions effectively in both normal and reversed-phase modes to resolve complex polar mixtures.
L10

Ultra-pure, unbonded spherical silica engineered for high-efficiency normal-phase separations. It provides optimal retention and resolution for polar compounds in organic mobile phases.
L3

A highly versatile aminopropyl phase suitable for normal-phase, HILIC, or weak anion-exchange chromatography. It is the recommended choice for precise carbohydrate and sugar analysis.
L8

Designed for challenging aqueous conditions. It features a specialized bonding process to resist phase dewetting, ensuring stable and reproducible retention of polar analytes even in 100% aqueous mobile phases.
L1

An aqueous-compatible C8 phase built for rapid equilibration and optimal peak shape when analyzing polar compounds under highly aqueous mobile phase conditions.
L7

A polar-embedded reversed-phase column designed to deliver exceptional peak symmetry for active basic compounds, while offering full compatibility and stability in 100% aqueous mobile phases.
L60

Seamlessly combines the pi-pi activity of a phenyl ring with the hydrophobic stability of a hexyl spacer. Ensures exceptional resolution for complex amine-containing and aromatic analytes.
L11

A pentafluorophenyl phase offering unique multi-mode interactions, including fluorophilic, dipole, and $pi-pi$. Unmatched in its ability to resolve halogenated compounds, positional isomers, and highly polar analytes.
L43

Engineered specifically for Hydrophilic Interaction Liquid Chromatography. Provides robust retention and superior peak shape for highly polar compounds that typically elute in the void volume of standard reversed-phase columns.
L3

The shortest-chain alkyl phase available. It delivers the lowest possible hydrophobicity, providing unique retention profiles ideal for separating non-polar analytes that are typically over-retained on longer-chain columns.
L13

A dimethylsilane phase that provides minimal hydrophobic interaction. It is engineered for ultra-fast analyses of highly retentive hydrophobic compounds, ensuring rapid elution and high throughput.

A high-quality butylsilane phase featuring low hydrophobic retention. It is the premier choice for the reliable separation and analysis of large molecules, peptides, and intact proteins without excessive retention.
L26

A hexylsilane bonded phase that offers intermediate hydrophobic retention. It perfectly bridges the selectivity gap between C4 and C8 columns, providing a balanced profile for analytes requiring moderate retention times.
L15

A premium triacontylsilane phase delivering exceptional shape selectivity. This column is essential for achieving baseline separation of complex geometric isomers, long-chain lipids, and carotenoids.
L62

Provides alternative selectivity to bare silica for normal-phase and HILIC applications. Offers enhanced hydrolytic stability and rapid equilibration times for polar analytes.
L20

A Strong Cation Exchange phase functionalized with sulfonic acid groups. Optimized for the robust retention and selective separation of basic and positively charged compounds.
L9

A Strong Anion Exchange phase featuring quaternary amine functionalities. Designed for the rigorous retention and high-resolution separation of acidic and anionic analytes.
L50

Features dual-ring pi-pi interactions that provide enhanced retention and superior orthogonal selectivity, making it highly effective for resolving aromatic and conjugated compounds.
L11

Zodiac Life Sciences delivers ultra-pure, high-performance HPLC columns built to meet the stringent demands of global analytical laboratories. Utilizing advanced, proprietary silica synthesis and innovative bonding technologies, our stationary phases—focusing on premium C18 and C8 chemistries—provide exceptional peak shape, reproducible selectivity, and extended column lifetime. Designed for seamless scalability from analytical validation to method development, Zodiac HPLC columns ensure uncompromising reproducibility and peak resolution for critical separations.
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