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Zodiac HPLC

Zodiac HPLC columns are designed using ultra-pure silica and controlled bonding technologies to deliver consistent and efficient separations across a wide range of analytical applications. The portfolio includes multiple chemistries to support reversed phase, normal phase, and HILIC methods.

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Phases

Reverse Phase (RP)

Zodiac C18

Zodiac C18

Recommended Use

The universal standard for reversed-phase chromatography. This premium octadecylsilane phase delivers high theoretical plates, robust retention, and exceptional resolution for a wide array of hydrophobic and moderately polar compounds.

USP Listing

L1

Particle Size (µm)
3,3.5,5,10
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Reverse Phase (RP)

Zodiac C8

Zodiac C8

Recommended Use

A high-performance octylsilane phase offering reduced hydrophobicity compared to C18. It provides significantly faster elution times for highly retained non-polar compounds while maintaining excellent peak symmetry.

USP Listing

L7

Particle Size (µm)
3,3.5,5,10
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Reverse Phase (RP)

Zodiac C18(1)

Zodiac C18(1)

Recommended Use

Engineered with an alternative carbon load and proprietary end-capping. This phase provides orthogonal selectivity to standard C18 columns, making it optimal for resolving closely eluting structural isomers.

USP Listing

L1

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C8(1)

Zodiac C8(1)

Recommended Use

A tailored C8 stationary phase developed to offer distinct alternative selectivity. It delivers rapid, highly efficient separations specifically targeted for moderately polar analytes.

USP Listing

L7

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac Phenyl

Zodiac Phenyl

Recommended Use

A robust phenyl bonded phase that provides distinct alternative selectivity to standard C18 columns, optimized specifically for the separation of aromatic and highly polarizable molecules.

USP Listing

L11

Particle Size (µm)
3,3.5,5,10
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Normal Phase (NP)

Zodiac CN

Zodiac CN

Recommended Use

A versatile cyanopropyl bonded phase known for its rapid equilibration. It functions effectively in both normal and reversed-phase modes to resolve complex polar mixtures.

USP Listing

L10

Particle Size (µm)
3,3.5,5,10
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Normal Phase (NP)

Zodiac Silica

Zodiac Silica

Recommended Use

Ultra-pure, unbonded spherical silica engineered for high-efficiency normal-phase separations. It provides optimal retention and resolution for polar compounds in organic mobile phases.

USP Listing

L3

Particle Size (µm)
3,3.5,5,10
View Details
Normal Phase (NP)

Zodiac Amino

Zodiac Amino

Recommended Use

A highly versatile aminopropyl phase suitable for normal-phase, HILIC, or weak anion-exchange chromatography. It is the recommended choice for precise carbohydrate and sugar analysis.

USP Listing

L8

Particle Size (µm)
3,3.5,5,10
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Reverse Phase (RP)

Zodiac C18 AQ

Zodiac C18 AQ

Recommended Use

Designed for challenging aqueous conditions. It features a specialized bonding process to resist phase dewetting, ensuring stable and reproducible retention of polar analytes even in 100% aqueous mobile phases.

USP Listing

L1

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C8 AQ

Zodiac C8 AQ

Recommended Use

An aqueous-compatible C8 phase built for rapid equilibration and optimal peak shape when analyzing polar compounds under highly aqueous mobile phase conditions.

USP Listing

L7

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac RP Amide

Zodiac RP Amide

Recommended Use

A polar-embedded reversed-phase column designed to deliver exceptional peak symmetry for active basic compounds, while offering full compatibility and stability in 100% aqueous mobile phases.

USP Listing

L60

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac Phenyl Hexyl

Zodiac Phenyl Hexyl

Recommended Use

Seamlessly combines the pi-pi activity of a phenyl ring with the hydrophobic stability of a hexyl spacer. Ensures exceptional resolution for complex amine-containing and aromatic analytes.

USP Listing

L11

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac PFP

Zodiac PFP

Recommended Use

A pentafluorophenyl phase offering unique multi-mode interactions, including fluorophilic, dipole, and $pi-pi$. Unmatched in its ability to resolve halogenated compounds, positional isomers, and highly polar analytes.

USP Listing

L43

Particle Size (µm)
3,3.5,5,10
View Details
HILIC

Zodiac HILIC

Zodiac HILIC

Recommended Use

Engineered specifically for Hydrophilic Interaction Liquid Chromatography. Provides robust retention and superior peak shape for highly polar compounds that typically elute in the void volume of standard reversed-phase columns.

USP Listing

L3

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C1

Zodiac C1

Recommended Use

The shortest-chain alkyl phase available. It delivers the lowest possible hydrophobicity, providing unique retention profiles ideal for separating non-polar analytes that are typically over-retained on longer-chain columns.

USP Listing

L13

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C2

Zodiac C2

Recommended Use

A dimethylsilane phase that provides minimal hydrophobic interaction. It is engineered for ultra-fast analyses of highly retentive hydrophobic compounds, ensuring rapid elution and high throughput.

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C4

Zodiac C4

Recommended Use

A high-quality butylsilane phase featuring low hydrophobic retention. It is the premier choice for the reliable separation and analysis of large molecules, peptides, and intact proteins without excessive retention.

USP Listing

L26

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C6

Zodiac C6

Recommended Use

A hexylsilane bonded phase that offers intermediate hydrophobic retention. It perfectly bridges the selectivity gap between C4 and C8 columns, providing a balanced profile for analytes requiring moderate retention times.

USP Listing

L15

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac C30

Zodiac C30

Recommended Use

A premium triacontylsilane phase delivering exceptional shape selectivity. This column is essential for achieving baseline separation of complex geometric isomers, long-chain lipids, and carotenoids.

USP Listing

L62

Particle Size (µm)
3,3.5,5,10
View Details
HILIC

Zodiac Diol

Zodiac Diol

Recommended Use

Provides alternative selectivity to bare silica for normal-phase and HILIC applications. Offers enhanced hydrolytic stability and rapid equilibration times for polar analytes.

USP Listing

L20

Particle Size (µm)
3,3.5,5,10
View Details
Ion Exchange (IEX)

Zodiac SCX

Zodiac SCX

Recommended Use

A Strong Cation Exchange phase functionalized with sulfonic acid groups. Optimized for the robust retention and selective separation of basic and positively charged compounds.

USP Listing

L9

Particle Size (µm)
3,3.5,5,10
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Ion Exchange (IEX)

Zodiac SAX

Zodiac SAX

Recommended Use

A Strong Anion Exchange phase featuring quaternary amine functionalities. Designed for the rigorous retention and high-resolution separation of acidic and anionic analytes.

USP Listing

L50

Particle Size (µm)
3,3.5,5,10
View Details
Reverse Phase (RP)

Zodiac Biphenyl

Zodiac Biphenyl

Recommended Use

Features dual-ring pi-pi interactions that provide enhanced retention and superior orthogonal selectivity, making it highly effective for resolving aromatic and conjugated compounds.

USP Listing

L11

Particle Size (µm)
3,3.5,5,10
View Details
zodiac_overview

Precision Chromatography. Defined by Absolute Accuracy.

Zodiac Life Sciences delivers ultra-pure, high-performance HPLC columns built to meet the stringent demands of global analytical laboratories. Utilizing advanced, proprietary silica synthesis and innovative bonding technologies, our stationary phases—focusing on premium C18 and C8 chemistries—provide exceptional peak shape, reproducible selectivity, and extended column lifetime. Designed for seamless scalability from analytical validation to method development, Zodiac HPLC columns ensure uncompromising reproducibility and peak resolution for critical separations.