Methods, application insights, and new column updates
Presto offers advanced Core-Shell HPLC columns engineered to deliver UHPLC-like efficiency, sharper peaks, faster separations, and exceptional reproducibility on conventional HPLC systems.


Presto C18 utilizes advanced core-shell technology to deliver sub-2 µm efficiency with standard HPLC backpressure. Featuring robust C18 bonding and protective endcapping, it provides exceptional peak shape and reproducibility for general method development.
L1

Presto Peptide C18 is engineered specifically for biomolecule separations, delivering narrow peak widths and superior resolution for peptide digests and synthetic peptides. Its core-shell particle architecture facilitates rapid mass transfer for complex biological samples.
L1

Presto C18 AQ features modified core-shell surface chemistry engineered to resist dewetting under 100% aqueous conditions. It enhances retention for polar analytes while maintaining rapid mass transfer and high efficiency.
L1

Presto CS C18 incorporates surface charge modification alongside robust C18 chemistry to prevent secondary silanol interactions. This delivers symmetrical peak shapes for basic analytes even when using formic acid or LC-MS friendly mobile phases.
L1

Presto XP C18 is built with enhanced particle technology that resists silica dissolution at elevated pH levels. It allows method developers to operate confidently across a broad pH range for optimized selectivity.
L1

Presto C8 AQ combines the faster elution profile of a C8 phase with complete stability in 100% aqueous mobile phases. It offers an ideal alternative when analytes exhibit excessive retention on C18 phases.
L7

Presto XP C8 provides robust performance under elevated pH conditions where standard C8 phases degrade. Its advanced core-shell technology ensures sharp peak shapes, lower backpressure, and fast analysis times.
L7

Presto CS C8 combines a surface-charged core-shell particle with C8 chemistry to eliminate peak tailing in basic analytes. It provides fast analysis speeds and excellent LC-MS compatibility for moderately hydrophobic molecules.
L7

Presto Peptide C8 is tailored for biomolecules and peptides that bind too strongly to C18 phases. Its core-shell structure accelerates mass transfer, enabling fast run times with high recovery and sharp resolution.
L7

Presto C8 provides moderate hydrophobic retention, eluting hydrophobic molecules faster than C18 while maintaining high resolution and peak symmetry. It is ideal for high-throughput screening and routine QC workflows.
L7

Presto C30 utilizes long alkyl chain chemistry on core-shell particles (120 Å pore size) to offer enhanced shape selectivity. It is uniquely suited for resolving closely related isomers, long-chain fatty acids, and lipophilic compounds.
L62

Presto Phenyl Hexyl features phenyl ring functionality attached via a hexyl alkyl spacer. It provides unique pi-pi interactions and complementary selectivity to standard alkyl phases for aromatic rings, nitroaromatics, and conjugated systems.
L11

Presto Bi Phenyl incorporates dual-ring aromatic chemistry on core-shell particles. It offers enhanced retention for electron-deficient aromatics, structural isomers, and polar pharmaceuticals that are difficult to separate on C18.
L11

Presto PFP combines electronegative fluorine atoms on a phenyl ring with core-shell efficiency. It excels in separating halogenated compounds, positional isomers, and basic molecules where alternative selectivity is required.
L43

Presto RP Amide incorporates an embedded amide group in the alkyl chain, eliminating silanol interactions and enhancing retention for phenolic, acidic, and hydroxylated compounds.
L60

Presto HILIC utilizes high-purity unbonded core-shell particles to retain highly polar analytes that elute near the void volume on reversed-phase columns. Ideal for LC-MS applications with high organic mobile phases.
L3

Presto CS Phenyl Hexyl integrates a surface charge with phenyl-hexyl chemistry to deliver exceptional peak symmetry for basic aromatic compounds under simple, MS-friendly mobile phase conditions.
L11

Presto® Core-Shell Technology combines proprietary nano-structured particles with precision in-house manufacturing to deliver UHPLC-like efficiency on conventional HPLC systems. The optimized core-shell architecture reduces diffusion paths, resulting in sharper peaks, faster separations, and superior resolution while maintaining manageable back pressure. This reflects the brochure's positioning and technical advantages.
Highlights:
Core-Shell Technology
<1% RSD
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Higher Plate Count
Lower Back Pressure
50+ QC Checks
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