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Separation of Caffeine

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Core-shell mixed-mode columns offer unique selectivity which comes from the presence of two mechanisms – reversed-phase and ion-exchange. The alternative selectivity of mixed-mode columns can be used when order of elution or resolution between compounds needs improvement. Even for neutral compounds a different selectivity can be obtained. A method for common components of headache medications (acetaminophen, caffeine, and benzoate) was developed on our Coresep 100 column. Efficiency and peak shape are comparable to leading brand core-shell reversed-phase columns.

Application Name : Selectivity Difference for Polar Compounds on Core-Shell Column in Reversed-Phase and Mixed-Mode

Column Name : Coresep 100 Columns

Analytes : Acetaminophen, Caffeine, Benzoic acid

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