Analysis Of 2,3-Dichlorobenzoic Anhydride on Zodiac HST S2 Column

HPLC Method for Analysis of 2,3-Dichlorobenzoic Anhydride

2,3-Dichlorobenzoic Anhydride, an impurity in Lamotrigine production, must be carefully monitored to ensure high purity of this anticonvulsant used for epilepsy and bipolar disorder treatment.

The impurity can be retained and analyzed using the Zodiac HST S2 mixed-mode column with a simple mobile phase of acetonitrile (MeCN) without water or buffer. The method provides high resolution and peak symmetry and enables UV detection at 210 nm.