Description
Prednisone, Prednisolone, and Methylprednisolone are potent corticosteroids with anti-inflammatory and immunosuppressive effects, widely used to manage inflammatory conditions, autoimmune disorders, allergies, and certain cancers.
- Prednisone: A synthetic corticosteroid that regulates gene expression by binding to glucocorticoid receptors.
- Prednisolone: The active metabolite of prednisone, converted in the liver, with similar therapeutic properties.
- Methylprednisolone: A more potent corticosteroid, effective in severe allergies, inflammation, and immunosuppression.
These corticosteroids can be efficiently separated and analyzed using the Zodiac HST B mixed-mode column. The method employs an isocratic mobile phase of water, acetonitrile (MeCN), and sulfuric acid, with UV detection at 245 nm for precise analysis.
Condition
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