Description
A complex mixture of nicotinamide and related impurities, including methylnicotinamide, nicotinamide adenine mononucleotide, nicotinamide adenine dinucleotide, and adenosine monophosphate, was baseline resolved within 15 minutes using the Zodiac HST TH trimodal column. This mixed-mode method employs reversed-phase, cation-exchange, and anion-exchange mechanisms, making it suitable for analyzing other nucleotides. Retention can be adjusted by varying the amount of ACN, buffer concentration, and buffer pH, with additional selectivity achieved by exploring different buffers within the same pH range.
Condition
Column Name : ZODIAC HST TH
Compound Name : Nicotinamide(NAM), 1-Methylnicotinamide(MNA), Nicotinamide Adenine Mononucleotide(NMN), Nicotinamide Adenine Dinucleotide (NAD+), Adenosine monophosphate(AMP)
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