Separation of Levamisole and Mebendazole in Pharmaceutical Formulations on Zodiac HST OG Column

Levamisole and Mebendazole are anthelmintic drugs used to treat parasitic worm infections. Levamisole paralyzes worms, aiding their expulsion, while Mebendazole disrupts glucose uptake, leading to worm death. Both are taken orally, with treatment varying by infection type. Proper hygiene is crucial to prevent reinfection.

Chromatographic Analysis:

Levamisole and Mebendazole can be retained and separated on a Zodiac HST OG reverse-phase column (3.2 x 100 mm, 5 µm, 100 Å) using a mobile phase of water, acetonitrile (MeCN), and sulfuric acid as a buffer.