Description
Tryptophan and Its Catabolites Analysis Using Zodiac HST OG Column
Tryptophan and its catabolites play crucial roles in protein synthesis, neurotransmission, and immune regulation. Key metabolites include:
Tryptophan: Essential amino acid, precursor to serotonin and melatonin.
Serotonin: Neurotransmitter regulating mood, appetite, and sleep.
Kynurenine Pathway Metabolites:
Kynurenine: Intermediate in tryptophan metabolism.
Kynurenic Acid: NMDA receptor antagonist with neuroprotective properties.
Xanthurenic Acid: Studied for its role in metabolic and neurological disorders.
3-Hydroxykynurenine: Can induce oxidative stress.
Quinolinic Acid: NMDA receptor agonist with neuroactive properties.
Indoleamine 2,3-Dioxygenase (IDO) Pathway: Regulates immune response and cell proliferation.
Tryptophan and its catabolites can be retained, separated, and analyzed using a Zodiac HST OG mixed-mode column with a gradient mobile phase of water, acetonitrile (MeCN), and sulfuric acid buffer, with UV detection at 220 nm.
Condition
Column Name : Zodiac HST OG
Compound Name :
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