Description
Nitroprusside, a nitric oxide donor used clinically for rapid blood pressure reduction, undergoes metabolic transformation into various breakdown products, including cyanide and thiocyanate. Accurate separation and quantitation of nitroprusside and its metabolites is essential for therapeutic monitoring and toxicity assessment.
Using the Zodiac HST B2 mixed-mode HPLC column, a robust method was developed to separate nitroprusside and its primary metabolites. The column’s reversed-phase and anion-exchange functionalities provide excellent retention and resolution of both the parent compound and its ionic degradation products.
Condition
Column Name : Zodiac HST B2
Compound Name :
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