HPLC Method for Analysis of Pamoic Acid on Zodiac HST B Column

Pamoic acid, also known as embonic acid, is widely used in the pharmaceutical industry for the formation of pamoate salts. These salts are commonly utilized to enhance the solubility, stability, and bioavailability of various drugs. Due to its ability to form stable complexes with a range of pharmaceutical compounds, pamoic acid plays a significant role in improving the therapeutic performance and formulation of medications.

Pamoic acid can be effectively retained and analyzed using a Zodiac HST B mixed-mode stationary phase column. The method employs an isocratic mobile phase composed of water, acetonitrile (MeCN), and sulfuric acid as a buffer. Detection is performed using UV at 235 nm, enabling accurate quantification of the compound.