HPLC Method for Analysis of Meclizine on Zodiac HST B Column

Meclizine is a synthetic piperazine and a histamine H1 receptor antagonist commonly used for the prevention and treatment of motion sickness, vertigo, and nausea during pregnancy. Possible side effects include drowsiness, dry mouth, and fatigue. Meclizine can be effectively analyzed using a reverse-phase Zodiac HST B mixed-mode column. The method is UV compatible and provides a reliable and robust approach, making it suitable for the analysis of meclizine and structurally related compounds.