HPLC Method for Analysis of Fenofibric Acid and Fenofibrate on Zodiac HST OG2 column

Description

Fenofibrate is a synthetic PPAR-α agonist and potent antilipemic agent used to reduce LDL cholesterol and triglycerides by enhancing lipid metabolism.

The Zodiac HST OG2 mixed-mode column (RP + ionic interaction) enables effective retention and separation of Fenofibrate due to its hydrophobic and weak ionic properties.

• Column: Zodiac HST OG2, 3.2 × 100 mm, 5 µm, 100 Å

• Mobile Phase: Acetonitrile/Water with phosphoric acid buffer

• Detection: UV compatible

This method offers sharp peaks, excellent resolution, and can be adapted for structurally similar lipid-regulating compounds.

Condition

1. Fenofibric Acid
2. Fenofibrate