HPLC Method for Analysis of Celebrex on Zodiac HST OG2 column

Description

Celecoxib, a COX-2 selective NSAID, is widely prescribed for the management of pain and inflammation related to arthritis, menstrual cramps, and acute musculoskeletal conditions.

Column & Retention
The Zodiac HST OG2, a mixed-mode reverse-phase column, enables selective retention of celecoxib through hydrophobic and ion-exchange interactions.

Mobile Phase
A  isocratic system of water, acetonitrile (MeCN), and phosphoric acid provides effective separation and peak resolution.

Detection
Detection is performed using UV at 270 nm, ensuring accurate quantification even at low concentrations.

Applications
Ideal for formulation analysis, stability studies, and routine quality control of celecoxib in pharmaceutical preparations.

Condition

1. Celebrex