HPLC Method for Analysis of Acetaminophen and Oxycodone on Zodiac HST- OG2 Column

Acetaminophen, a p-aminophenol derivative, exhibits analgesic and antipyretic properties with minimal anti-inflammatory effects. However, it may cause liver, blood cell, and kidney damage at high doses. It is commonly used as an over-the-counter medication for managing mild to moderate pain and fever.

Oxycodone is a semi-synthetic opioid used to relieve moderate to severe pain. The Zodiac HST OG2 reverse-phase column, which features embedded acidic ionizable groups, effectively retains both Acetaminophen and Oxycodone. This UV-compatible method provides a reliable and versatile approach for the analysis of similar compounds.