HPLC Determination of Perindopril on Zodiac HST- OG2 Column

Description

Perindopril, an ACE inhibitor commonly prescribed for managing hypertension, can be efficiently retained and analyzed on the Zodiac HST OG2 mixed-mode column. Featuring embedded weak acidic ion-pairing groups, the Zodiac HST OG2 provides strong retention and excellent peak shape for basic compounds. Using a straightforward isocratic mobile phase consisting of water, acetonitrile (MeCN), and a sulfuric acid (H₂SO₄) buffer, Perindopril is eluted in under 8 minutes with high resolution and reproducibility—ideal for routine pharmaceutical applications.

Condition

1. Perindopril