HPLC Analysis of Codeine-Containing Drug Formulation: Influence of Buffer Concentration and pH on Separation

Home HPLC Analysis of Codeine-Containing Drug Formulation: Influence of Buffer Concentration and pH on Separation

Description

The separation of codeine in pharmaceutical formulations was achieved using mixed-mode HPLC. The method demonstrates how buffer concentration and pH significantly influence retention and selectivity, enabling fine-tuning of separation conditions for optimal resolution.

Condition

 

 

 

Column Name : Zodiac HST C

Compound Name :

  1. Codeine
  2. Methyl Paraben
  3. Propyl Paraben

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