HPLC Analysis of Acidic Drugs and Counter-Ions on Zodiac HST TH Column

Mixed-mode chromatography enables simultaneous quantitation of drugs and their counter-ions in a single run. Using the Zodiac HST TH trimodal HPLC column, both hydrophobic acidic drugs and hydrophilic inorganic counter-ions can be efficiently separated and quantified. This column is versatile and supports the analysis of a wide range of compounds, including hydrophilic and hydrophobic acidic or basic drugs, along with their organic and inorganic counter-ions.

The method is compatible with various detection techniques such as ELSD, UV, CAD, and LC/MS, ensuring robust and reliable quantitation. The Zodiac HST TH column retains ionizable compounds without the need for ion-pairing reagents, making it an excellent universal platform for analyzing basic and acidic drugs and their corresponding counter-ions.