Analysis of Tyramine on Zodiac HST OG Column

Tyramine is a biogenic amine derived from tyrosine, found in aged and fermented foods.

Key Points:

• Occurrence: Present in aged cheese, fermented soy, wine, and cured meats.

• Biological Role: Acts as a neurotransmitter and influences blood pressure.

• Food Sensitivity: Can trigger headaches and hypertension in susceptible individuals.

• Drug Interaction: Dangerous with MAOIs, potentially causing hypertensive crises.

• Metabolism: Broken down by monoamine oxidase (MAO); MAOI use increases risk.

Tyramine can be retained and analyzed using a Zodiac HST OG mixed-mode column with an isocratic method (water, MeCN, sulfuric acid buffer) and UV detection at 222 nm.