Analysis of Tizanidine on Zodiac HST- OG2 Column

Description

Tizanidine, sold under the brand name Sirdalud, is used to treat spasticity in conditions like multiple sclerosis and spinal cord injury. It works by blocking nerve impulses, helping to relax muscles.

Common side effects include low blood pressure, dry mouth, weakness, drowsiness, and liver injury. It can interact with antidepressants, antibiotics, and blood pressure medications, so informing your doctor about all current medications is essential.

Tizanidine may cause dependence, and should be tapered off gradually under medical supervision to avoid withdrawal symptoms.

This compound can be effectively analyzed using a Zodiac HST OG2 mixed-mode column with a mobile phase of water, acetonitrile (MeCN), and phosphoric acid (H₃PO₄). UV detection at 228 nm ensures high resolution and sharp peak symmetry.

Condition

1. Tizanidine