Analysis of Sertraline on Zodiac HST B

Sertraline, an antidepressant in the selective serotonin reuptake inhibitor (SSRI) class, is widely prescribed for depression, anxiety disorders, OCD, panic attacks, PTSD, and social anxiety. It works by increasing serotonin levels in the brain through reuptake inhibition, helping regulate mood, reduce anxiety, and improve mental health.

Sertraline is commonly used to treat major depressive disorder (MDD), generalized anxiety disorder (GAD), panic disorder, obsessive-compulsive disorder (OCD), PTSD, and social anxiety disorder.

The retention, separation, and analysis of sertraline can be efficiently performed using the Zodiac HST B mixed-mode stationary phase column. The method employs a gradient approach with a mobile phase consisting of water, acetonitrile (MeCN), and sulfuric acid as a buffer. Detection is carried out at UV 195 nm, ensuring accurate and reliable results.