Description
Biguanides such as Moroxydine, Metformin, Proguanil, and Phenformin share a common structural backbone with two guanidine groups.
Phenformin, once used for type 2 diabetes, was withdrawn in many countries due to the risk of lactic acidosis.
These biguanides have diverse applications, including antidiabetic, antiviral, and antimalarial treatments, requiring careful medical supervision.
Phenformin can be retained and analyzed using a Zodiac HST OG mixed-mode column with an isocratic method (water, MeCN, ammonium formate buffer) and UV detection at 240 nm.
Condition
* LOD was determined for this combination of instrument, method, and analyte, and it can vary from one laboratory to another even when the same general type of analysis is being performed.
Column Name : Zodiac HST OG
Compound Name : Phenformin
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