Analysis of Evogliptin and Mannitol in Pharmaceutical Dosage Form on Zodiac HST-OG2 Column

Description

Evogliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor used primarily in the treatment of type 2 diabetes mellitus. By inhibiting the DPP-4 enzyme, it increases the levels of incretin hormones, such as GLP-1 (glucagon-like peptide-1). This enhancement stimulates insulin release and suppresses glucagon secretion, helping to regulate blood sugar levels in diabetic patients.

Evogliptin can be effectively retained and analyzed using a Zodiac HST OG2 mixed-mode stationary phase column. The analysis follows an isocratic method with a mobile phase consisting of water, acetonitrile (MeCN), and ammonium formate as a buffer. Detection is performed using UV at 265 nm.

Condition

1. Mannitol
2. Evogliptin