Analysis of Cariprazine on Zodiac HST B

Cariprazine is an atypical antipsychotic medication commonly prescribed for the management of schizophrenia and bipolar disorder. It works by partially activating dopamine D2 and D3 receptors, with a strong affinity for D3, and also modulates serotonin receptor activity (5-HT1A agonism and 5-HT2B/5-HT2A antagonism). This distinctive mechanism helps balance neurotransmitters in the brain, effectively alleviating symptoms like hallucinations, delusions, and mood fluctuations.

Key Benefits: Cariprazine is effective in addressing both the positive symptoms of schizophrenia (such as hallucinations and delusions) and the negative symptoms (like social withdrawal and apathy). Its D3 receptor selectivity may reduce common side effects associated with other antipsychotics, including sedation and weight gain.

Cariprazine can be accurately retained, separated, and analyzed using the Zodiac HST B mixed-mode stationary phase column. The analysis involves a gradient method with a mobile phase containing water, acetonitrile (MeCN), and formic acid as a buffer. Detection is carried out at UV 260 nm, providing reliable and precise results.