Analysis of Antibiotic Dapsone and Related Impurities in Mixed-Mode Chromatography

Dapsone is an antibiotic commonly used in the treatment of leprosy and acne. Zodiac HST TH, a trimodal column offering reversed-phase, cation-exchange, and anion-exchange capabilities, was employed for the analysis of dapsone and its related impurities. This method is compatible with both LC/MS detection and preparative chromatography, providing a robust approach for accurate and efficient separation.