HPLC Separation of Alendronic, Etidronic Acids, Ibandronic

Home HPLC Separation of Alendronic, Etidronic Acids, Ibandronic

Description

Alendronic, ibandronic, and etidronic acids, bisphosphonates used in treating bone diseases, can be efficiently separated using a short 50 mm Zodiac HST SB column. The method employs a mobile phase of water, acetonitrile (MeCN/ACN), and trifluoracetic acid (TFA) or ammonium formate, with evaporative light scattering detection (ELSD) at 80°C.

Condition

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