Zodiac HST OG
Zodiac HST OG Column:
Unmatched Versatility in Mixed-Mode Chromatography.
The Zodiac HST OG column is a cutting-edge analytical tool engineered to address the most complex separations. Featuring a pKa value of 1, this mixed-mode column integrates acidic ion-pairing groups with long hydrophobic ligand chains, offering unparalleled versatility for separating a broad range of analytes. With enhanced retention, selectivity, and reproducibility, the Zodiac HST OG is the ideal choice for tackling challenging chromatographic applications across industries.
Why choose Zodiac HST OG?
The Zodiac HST OG column delivers exceptional performance through its multi-modal interactions and low pKa value, ensuring precise and reliable separations across various applications. Its superior selectivity and flexibility make it the ideal solution for separating complex mixtures in fields ranging from pharmaceuticals and bioanalysis to chemical research.
Transform your chromatographic workflows with the Zodiac HST OG column—where innovation meets precision.
Multi-Mode Separation:
- Cation-Exchange Mechanism: Enhances the retention and separation of basic compounds by interacting with their positive charges.
- Ion-Exclusion Mechanism: Effectively separates acidic compounds by selectively excluding them based on their ionic form.
- Reverse-Phase Retention: Efficiently retains neutral compounds with high selectivity and reproducibility.
pKa Value of 1:
The low pKa value ensures strong interaction with weak basic analytes, making the column especially effective at retaining basic compounds and excluding acids under low-pH conditions. At pKa values below 1, it functions similarly to a standard reverse-phase column, enhancing flexibility in method development
Mobile Phase Compatibility:
- Fully compatible with LC-MS, preparative chromatography, and low UV detection applications.
- Offers the flexibility to adjust the mobile phase composition for optimal separation under diverse conditions.
Details Will be updated soon…!
The Zodiac HST OG column is designed for a broad range of applications, including:
- Pharmaceutical Analysis: Ideal for the precise separation of active pharmaceutical ingredients (APIs), impurities, and metabolites.
- Bioanalytical Testing: Perfect for analyzing complex biological matrices, such as plasma and serum samples.
- Chemical and Industrial Analysis: Efficiently resolves mixtures containing acidic, basic, and neutral compounds.
- Typical mobile phases used with HST OG columns are based on acetonitrile, water, and an acid buffer such as HClO4, H2SO4 or H3PO4, and the like. Mass spectrometry-compatible buffers ammonium formate (pH 3) and ammonium acetate (pH 5) can also be used. If it is necessary to detect in low UV (<220 nm) then a phosphate buffer is recommended.
- Available in various particle sizes to suit your specific needs:
- 10 µm, 5 µm, 3 µm fully porous, and 2.7 µm solid-core particles.
- Available in standard dimensions for broad application versatility.
Support will be updated very soon…!
Get In Touch
Get Your Quote or Call: 040-29881474
We focus on supporting laboratory workflows & optimizing lab-wide operations