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Related Substances Of Isavuconazonium Sulfate
Application ID :
AP_1162
Analytes
- Impurity-A, Impurity-B, Isavuconazonium Sulfate, Impurity-C, Unknown Impurity-1, Impurity-D, Unknown Impurity-2, Unknown Impurity-3, Unknown Impurity-4, Isavuconazonium Sulfate ST-1
Conditions
Column : Zodiac 120 RP Amide
Column Size : 250mm * 4.6mm, 5mu*m
Mobile Phase :
M.P.A: 1.36g of KH2PO4 in 950ml water & Adjust pH 3.0 With H3PO4 and dilute with Water to 1L
M.P.B: Acetonitrile
Flow Rate : 0.8 ml/min
Buffer Details : Isavuconazonium sulfate is a prodrug of Isavuconazole, an antifungal medication used to treat invasive aspergillosis and invasive mucormycosis. When analyzing Isavuconazonium sulfate for related substances using a RP-Amide column, several considerations come into play. the RP-Amide column is selected for its specific selectivity in separating polar compounds like Isavuconazonium sulfate and its related substances. Method development and validation are critical steps to ensure accurate and reliable analysis in pharmaceutical quality control.
Detector : UV 265 nm & 240nm
Column Temperature : 30°C
Sample Temperature : 5°C
Injection Volume : 10μι
Diluent/Sample Solvent : Acetonitrile: Water (80:20) v/v
Description
Isavuconazonium sulfate is a prodrug of Isavuconazole, an antifungal medication used to treat invasive aspergillosis and invasive mucormycosis. When analyzing Isavuconazonium sulfate for related substances using a RP-Amide column, several considerations come into play. the RP-Amide column is selected for its specific selectivity in separating polar compounds like Isavuconazonium sulfate and its related substances. Method development and validation are critical steps to ensure accurate and reliable analysis in pharmaceutical quality control.
