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Related substances for Finerenone API by HPLC
Application ID :
AN-1225/2
Analytes
- 1.Peak1 2.Finerenone 3. Peak2 4. Peak3
Conditions
Column : Presto 120 C8 AQ Column
Column Size : 150mm*4.6mm, 2.7µm
Mobile Phase :
Preparation of mobile phase-A : T Take 1000ml of water and
add1 ml of triflouroacetic acid and sonicare for degas.
Preparation of mobile phase-B : Mix Water: acetonitrile (50:50%
v/v) and sonicate for degas
Flow Rate : 0.5 mL/min
Detector : UV 242 nm
Elution Mode : Gradient program
Run Time : 55 min
Column Temperature : 20°C
Injection Volume : 10 µL
Description
Finerenone (often handled in its base form or specific salt configurations
like oxalate during chemical development) belongs to the drug category of
Non-Steroidal Mineralocorticoid Receptor Antagonists (MRAs).In accurate
analysis of the active pharmaceutical ingredient requires effective
separation of Finerenone from its related impurities.This HPLC application
demonstrates the separation of Finerenone using a Presto 120 C8 AQ
column. The method provides a clear chromatographic profile with
Finerenone eluting at approximately 11.318 minutes, while the observed
impurities are separated at approximately 10.026, 12.982 and 22.850
minutes.
like oxalate during chemical development) belongs to the drug category of
Non-Steroidal Mineralocorticoid Receptor Antagonists (MRAs).In accurate
analysis of the active pharmaceutical ingredient requires effective
separation of Finerenone from its related impurities.This HPLC application
demonstrates the separation of Finerenone using a Presto 120 C8 AQ
column. The method provides a clear chromatographic profile with
Finerenone eluting at approximately 11.318 minutes, while the observed
impurities are separated at approximately 10.026, 12.982 and 22.850
minutes.
