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Palbociclib SST Analysis using Zodiac C18(1) Column

Application ID : AP_1152

Analytes

  1. Polbociclib pyridine N-oxide, Boc-Amino pyridinylpiperzine, Des acetyl impurity, Palbociclib, Palbociclib piperazine N-oxide, Palbociclib Despyridyl analog, Palbociclib Despyridyl bromo analog, 6-Desacetyl-6-bromo-N-Boc-Polbociclib, Palibociclib N-Boc Allyl analog
Conditions

Column : Zodiac C18(1)

Column Size : 250mmx4.6mm,5µm

Mobile Phase :
3.4 g KH2PO4 in 1000 mL water, adjusted to pH 4.0 with dil OPA
Acetonitrile:Methanol (70:30)

Flow Rate : 1.2mL / min

Description
A robust and reliable HPLC method designed for the analysis of Palbociclib SST using the Zodiac C18(1) column (250mm × 4.6mm, 5µm). This method ensures high precision, superior resolution, and consistent performance, making it well-suited for pharmaceutical quality control and impurity assessment.