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USP Assay for Cefpodoxime proxetil API by HPLC
Application ID :
AN-1231
Analytes
- 1.Cefpodoxime proxetil S-Isomer 2.Cefpodoxime proxetil R-Isomer
Conditions
Column : Presto 120 C18
Column Size : 150mm x 4.6mm,2.7µm
Mobile Phase :
Preparation of mobile phase : Use filtered and degassed
Buffer: Acetonitrile ( 60:40)
Mobil phase: Use varible mixtures of Solution A and Solution B
as directed for chromatographic system. Make adjustments if
necessary.
Flow Rate : 0.5 mL/min
Buffer Details : Preparation of Buffer: Prepare filtered and degassed 0.02M ammonium acetate.
Detector : UV 235 nm
Elution Mode : Isocratic
Run Time : 25 min
Column Temperature : 30°C
Injection Volume : 20 µL
Description
Cefpodoxime proxetil is a third-generation oral cephalosporin antibiotic. It
stops bacterial growth by preventing bacteria from forming their protective
cell walls.In accurate analysis of the active pharmaceutical ingredient
requires effective separation of Cefpodoxime proxetil R-Epimer and
Cefpodoxime proxetil S-Epimer .This HPLC application demonstrates the
separation of Cefpodoxime proxetil R-Epimer and Cefpodoxime proxetil
S-Epimer using a Presto 120 C18 column. The method provides a clear
chromatographic profile with Cefpodoxime proxetil S-Epimer and
Cefpodoxime proxetil R-Epimer eluting at approximately 13.702 and
15.182 minutes.
stops bacterial growth by preventing bacteria from forming their protective
cell walls.In accurate analysis of the active pharmaceutical ingredient
requires effective separation of Cefpodoxime proxetil R-Epimer and
Cefpodoxime proxetil S-Epimer .This HPLC application demonstrates the
separation of Cefpodoxime proxetil R-Epimer and Cefpodoxime proxetil
S-Epimer using a Presto 120 C18 column. The method provides a clear
chromatographic profile with Cefpodoxime proxetil S-Epimer and
Cefpodoxime proxetil R-Epimer eluting at approximately 13.702 and
15.182 minutes.
