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USP Assay for Atomoxetine Hydrochloride by HPLC

Application ID : AN-1234

Analytes

  1. Atomoxetine Hydrochloride
Conditions

Column : Presto 120 C8 AQ Column

Column Size : 150mm x 4.6mm,2.7µm

Mobile Phase :
n-propyl alcohol and buffer (27:73). (Note: The ratio of in Buffer be varied between 26:74 and 29:71 to meet system suitability requirements.)
Solution A : 280g/L of potassium hydroxide in water.

Flow Rate : 0.5 mL/min

Buffer Details : 2.9 g/L of in Adjust with solution A to a pH of 2.5 to 1.0L of this solution add 5.9 g of octanesulfnnic acid sodium salt monohydrate

Detector : UV 215 nm

Elution Mode : Isocratic

Run Time : 25 min

Column Temperature : 40°C

Injection Volume : 10 µL

Description
Atomoxetine Hydrochloride is a non-stimulant selective norepinephrine reuptake inhibitor (SNRI) primarily prescribed to treat Attention-Deficit/ Hyperactivity Disorder (ADHD) in children (aged 6 and older), adolescents, and adults.The method provides a clear chromatographic peak of Atomoxetine eluting at ,13.465 minutes.