Analysis of Antibiotic Marbofloxacin and Related Impurities in Mixed-Mode Chromatography

Marbofloxacin is a carboxylic acid derivative belonging to the fluoroquinolone class of antibiotics. A robust analytical method was developed for the separation of marbofloxacin and its related impurities using Zodiac HST RP mixed-mode columns. Zodiac HST RP offers mixed-mode functionality with reversed-phase and anion-exchange characteristics, enabling effective resolution of structurally related impurities.